Overview

Metallic implants (Ti ,Co ,SS etc.) that are presently being used remain permanently in the body and cause long term side effects like systemic toxicity, chronic inflammation, thrombosis and stress-shielding; which necessitate a secondary surgical intervention. The BD implants are expected to corrode gradually in vivo, with an appropriate host response elicited by released corrosion products, which are metabolized or assimilated by cells and/or tissue. The implants dissolve completely upon fulfilling the mission to assist with tissue healing with no residues.

ARCI has developed noble biodegradable (BD) alloys (Mg-Zn and Fe-Mn) for various implant applications such as stent, screw, soft tissue anchors on pilot scale. The soft tissue anchors (STAs) were built by powder bed fusion additive manufacturing using noble alloy compositions and powders. A very good mechanical (YS > 417 MPa) and magnetic (2.2x10-7 m3kg-1) properties , excellent degradation rate (0.25 mmpy) with very good biocompatibility  for Fe-Mn based BD has been achieved. Similarly, an excellent combination of mechanical (YS > 225 MPa ) and degradation rate (0.04 mmpy) with good biocompatibility has been achieved for Mg-Zn BD alloy as well. The in-vivo testing are being tested on the implants.

Key Features

  •     Temporary implant; Elimination of secondary surgery
  •     Avoid stress-shielding and thrombosis
  •     Excellent mechanical properties and degradation rate
  •     Non-cytotoxic to HOS cells

Potential Applications

  •     Implant Materials for Bone Surgery: Plates, Screws, Pins, etc.
  •     Stents: Vascular, Coronary, Ureteral, Prostatic, Pancreatic and Biliary, Colon etc.
  •     Tissue Engineering : Hard and Soft Tissue Anchors /Scaffold

Status

  •     Processing and properties are validated at laboratory scale
  •     Coupon level demonstrated

Intellectual Property Development Index (IPDI)

Level 1 2 3 4 5 6 7 8 9 10
Description Basic concepts and understanding of underlying scientific principles Shortlisting possible applications Research to prove technical feasibility for targeted application Coupon level testing in simulated conditions Check repeatability/consistency Prototype testing in real-life conditions Check repeatability/consistency Reassessing feasibility (IP, competition technology, commercial) Initiate technology transfer Support in stabilizing production
Status

For more details on Intellectual Property Development Indices, Click here

  1. Kaliyan Hembram et al.  entitled “Fe-Mn  based      Alloy  Composition  and Methods   of Fabricating Biodegradable Implants Using the Same” “  Provisional Indian Patent Filed No. 202541029825 dt 28-04-2024.
  2. H. Kumar, S.Dutta, R.Vijay and K. Hembram “ A Zirconium oxide layer based Mg-Zn-Zr alloys and its method of preparation thereof “ Indian Patent Application No. 202341055508 dated 18-08-2023

  1. D. Spandana, Hemin Desai, D. Chakravarthy, R.Vijay and K. Hembram, Fabrication of a Biodegradable Fe-Mn-Si Alloy by Field Assisted Sintering, Advanced Powder Technology, 31, 12, 4577-4584, 2020